Erscheinungsdatum: 13.05.2016, Medium: Buch, Einband: Gebunden, Titel: Epigenetic Advancements in Cancer, Auflage: 1. Auflage von 2016 // 1st ed. 2016, Redaktion: Bishnupuri, Kumar S. // Mishra, Manoj K., Verlag: Springer International Publishing // Springer International Publishing AG, Sprache: Englisch, Schlagworte: Erblehre // Genetik // Krebs // Krankheit // Tumor // Medizin, Rubrik: Allgemeinmedizin // Diagnostik, Therapie, Seiten: 260, Informationen: HC runder Rücken kaschiert, Gewicht: 539 gr, Verkäufer: averdo
Advancements in Tumor Immunotherapy and Cancer Vaccines ab 155 EURO
Because of tremendous advancements in research,neurosurgical oncology has become increasingly complex, and it is imperativethat physicians have scientific evidence to guide and defend their decisionmaking as they strive to provide the best patient care. Controversies inNeuro-Oncology: Best Evidence Medicine for Brain Tumor Surgery, written byworld-renowned experts, is a comprehensive guide that compiles, synthesizes, andsummarizes the most relevant scientific literature available in neurosurgicaloncology. It provides objective recommendations based on the data found inthe literature, giving physicians the information they need to make fullyinformed treatment decisions.Key Features:An opening chapter,Introduction to Best Evidence Medicine, illustrates how the authors rate theviability of the data presentedAuthors discuss in detail commonlydisputed topics specific to tumor type, such as the roles of surgery and grosstotal resection as well as radiosurgery optionsExpert recommendationboxes highlight "takeaways" for the readerSummary tables distillabundant scientific evidence and emphasize the main conclusions of publishedstudiesThis book will be the go-to guide for all neurosurgeons,oncologists, and neurologists involved in the multidisciplinary care of patientswith brain tumors.
Tumor markers are substances found in the human body, usually in blood, urine or body tissues that can be elevated in cancer. So, they are biochemical indicators of the presence of a tumor. We can detect specific cancer by various laboratory techniques & provide therapeutic benefit to the patient. With advances in technology, researchers are more inclined towards genomics, proteomics, serum biomarkers, salivary markers etc. to detect tumor or malignancy at the earliest. Thus, this book briefly comprises of tumor markers of common systemic, oral & paraoral malignancies with their laboratory techniques and recent advancements which thereby greatly promote progress towards novel diagnostic & predictive tools for early detection of cancer. This book is very useful for students in medical, dental, researchers and professionals.
One of the greatest challenges facing the computational engineering community is to extend the success of computational mechanics to fields outside traditional engineering, in particular to biology, the biomedical sciences and medicine. The Computational Biomechanics for Medicine series provides an opportunity for specialists in computational biomechanics to present their latest methodologies and advancements. This 5th edition comprises nine of the latest developments in both fundamental science and patient-specific applications, from researchers in Australia, New Zealand, USA, UK, France, Ireland and China. Some of the interesting topics discussed are: cellular mechanics, tumor growth and modeling, medical image analysis and both patient-specific fluid dynamics and solid mechanics simulations. One of the greatest challenges facing the computational engineering community is to extend the success of computational mechanics to fields outside traditional engineering, in particular to biology, the biomedical sciences and medicine. The Computational Biomechanics for Medicine series provides an opportunity for specialists in computational biomechanics to present their latest methodologies and advancements. This 5th edition comprises nine of the latest developments in both fundamental science and patient-specific applications, from researchers in Australia, New Zealand, USA, UK, France, Ireland and China. Some of the interesting topics discussed are: cellular mechanics, tumor growth and modeling, medical image analysis and both patient-specific fluid dynamics and solid mechanic simulations.
This book presents our experience in the operative treatment of bone and soft-tissue tumors arising in and around the pelvis, from 1970 to 1999 in the Department of Orthopedic Surgery at the Niigata University Medical Hospital. Histological diagnoses included both benign and malignant tumors. Surgical plan ning was difficult to perform in our early experience in operative treatment, when only angiography and barium enemas were in use. In the meantime, computed tomog raphy scanning and magnetic resonance imaging became available. Subsequent improvement in the quality of these images made three-dimensional surgical plan ning for pelvic tumor removal much easier. Such progress in diagnostic methodolo gies, together with advancements in microsurgical techniques, methods of irradiation, and various adjuvant chemotherapies has led to significant improvements in the treat ment of pelvic tumors. Furthermore, these advancements were enhanced by the avail ability of various conventional and custom-made endoprostheses, plates and screws, spinal instruments, and external fixators made of 3161 stainless steel, titanium, high density polyethylene, and ceramics. Because sacral tumors are so silent and symptomless, they may grow to a large size and be difficult to excise. Removal of sacral tumors might make subjective symptoms worse because the sacrum contains the cauda equina. Excision of a tumor that involves the ilium and sacroiliac joint may interrupt the structural stability of the pelvic ring. A tumor affecting the hip joint may require reconstruction to re-establish the func of the hip and to provide stability for gait after operative treatment.
This volume examines every major topic area in the modern era of renal carcinoma biology and treatment. The unique and intricate genetics of this cancer are highly distinct from most other tumors, and the advances made in this cancer beyond VHL biology have been intrinsically driven by discoveries from familial renal cell carcinomas linked with newer large scale genomic efforts in sporadic disease. These genetic findings fuel strategies to analyze and define sporadic tumors for greater accuracy in prognosis and prediction of response to therapy. Additional topics include major new therapeutic strategies that harness these biological discoveries, in particular angiogenic, energy metabolism, chromatin remodeling, tumor microenvironment, and classical signaling pathways. This text will bring all of these avenues of investigation together for readers interested in understanding the dynamics of this field in the last decade and anticipating a continued steep trajectory in advancements toward the cure of this disease in its many manifestations.
miRNAs are a class of endogenous, small non-protein coding RNA molecules (~ 22 nucleotides) which are novel post-transcriptional regulators of gene expression. Since we have hundreds of miRNAs, the major challenge is now to understand their specific biological function. In fact the experimental evidence suggests that signaling pathways could be ideal candidates for miRNA-mediated regulation. Several studies suggest that miRNAs affect the responsiveness of cells to signaling molecules such as WNT, Notch, TGF-beta and EGFR. Altered expression of particular miRNAs has been implicated in the onset and development of cancer and could be used as potential biomarkers for the disease.Recently, many studies have found miRNAs have crucial regulatory roles in Cancer stem cells (CSCs) a kind of tumor initiating cells (TICs) and dormancy. Findings also suggest that DNA methylation may be important in regulating the expression of many miRNAs in several cancer initiating cells. Several miRNAs are known to either upregulated or downregulated in CSCs when compared to non-cancerous cells from the same tissues. CSCs are a small subpopulation of cells identified in a variety of tumors and involve in self-renewal, differentiation, chemoresistance and tumorigenesis. The volume will give a comprehensive account of important advancements in the area of miRNAs and cancer.
Understanding the importance and necessity of the role of autophagy in health and disease is vital for the studies of cancer, aging, neurodegeneration, immunology, and infectious diseases. Comprehensive and up-to-date, this book offers a valuable guide to these cellular processes whilst inciting researchers to explore their potentially important connections.Volume 5 comprehensively describes the role of autophagy in human diseases, delivering coverage of the antitumor and protumor roles of autophagy, the therapeutic inhibition of autophagy in cancer, and the duality of autophagy's effects in various cardiovascular, metabolic, and neurodegenerative disorders. In spite of the increasing importance of autophagy in the various pathophysiological conditions mentioned above, this process remains underestimated and overlooked. As a consequence, its role in the initiation, stability, maintenance, and progression of these and other diseases remains poorly understood.This book is an asset to newcomers as a concise overview of the diverse disease implications of autophagy, while serving as an excellent reference for more experienced scientists and clinicians looking to update their knowledge.Volumes in the SeriesVolume 1: Molecular Mechanisms. Elucidates autophagy's association with numerous biological processes, including cellular development and differentiation, cancer, immunity, infectious diseases, inflammation, maintenance of homeostasis, response to cellular stress, and degenerative diseases such as Alzheimer's, Parkinson's, Huntington's, amyotrophic lateral sclerosis, and prion diseases. Volume 2: Role in General Diseases. Describes the various aspects of the complex process of autophagy in a myriad of devastating human diseases, expanding from a discussion of essential autophagic functions into the role of autophagy in proteins, pathogens, immunity, and general diseases. Volume 3: Role in Specific Diseases. Explores the role of autophagy in specific diseases and developments, including: Crohn's Disease, Gaucher Disease, Huntington's Disease, HCV infection, osteoarthritis, and liver injury, with a full section devoted to in-depth exploration of autophagy in tumor development and cancer, as well as the relationship between autophagy and apoptosis. Volume 4: Mitophagy. Presents detailed information on the role of mitophagy, the selective autophagy of mitochondria, in health and disease, by delivering an in-depth treatment of the molecular mechanisms involved in mitophagy initiation and execution, as well as the role of mitophagy in Parkinson Disease, cardiac aging, and skeletal muscle atrophy. Volume 5: Role in Human Diseases. Comprehensively describes the role of autophagy in human diseases, delivering coverage of the antitumor and protumor roles of autophagy, the therapeutic inhibition of autophagy in cancer, and the duality of autophagy's effects in various cardiovascular, metabolic, and neurodegenerative disorders. Volume 6: Regulation of Autophagy and Selective Autophagy. Provides coverage of the mechanisms of regulation of autophagy, intracellular pathogen use of the autophagy mechanism, the role of autophagy in host immunity, and selective autophagy. Volume 7: Role of Autophagy in Therapeutic Applications. Provides coverage of the latest developments in autophagosome biogenesis and regulation, the role of autophagy in protein quality control, the role of autophagy in apoptosis, autophagy in the cardiovascular system, and the relationships between autophagy and lifestyle. Volume 8: Autophagy and Human Diseases. Reviews recent advancements in the molecular mechanisms underlying a large number of genetic and epigenetic diseases and abnormalities, and introduces new, more effective therapeutic strategies, in the development of targeted drugs and programmed cell death, providing information that will aid on preventing detri