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Tumor Angiogenesis
309,99 € *
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Preface Tumor development and progression occur as a result of cumulative acquisition of genetic alterations affecting oncogenes and tumor suppressor genes. As a consequence of these alterations the arising tumor gains some fatal properties such as increased cell proliferation and decreased apoptosis, resulting in a net accumulation of tra- formed cells. Once a critical volume is achieved, lack of oxygen and nutrients limits further growth. To overcome this obstacle, the tumor cells initiate a program focused on the formation of new blood vessels within the host tissue. This process is termed tumor angiogenesis and contributes to the progression of most solid tumors and the formation of metastases. Since its discovery more than 30 years ago by Dr. Judah Folkman, tumor angiog- esis has been proposed as an ideal target for novel tumor therapies. Today the first anti-angiogenic compounds are available for the treatment of patients but their s- cess in the clinic is rather limited when given as monotherapies. This is in contrast to many preclinical results which revealed a much higher efficacy of these therapeutics in appropriate animal models. The reasons for this discrepancy are manifold, one being the existence of more than one angiogenic signaling system capable of driving tumor angiogenesis. Therefore it is no surprise that the inhibition of just one system is not sufficient to block the formation of new blood vessels in patients.

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Stand: 07.12.2019
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Tumor Angiogenesis
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Erscheinungsdatum: 17.02.2012, Medium: Buch, Einband: Gebunden, Titel: Tumor Angiogenesis, Redaktion: Ran, Sophia, Verlag: IntechOpen, Sprache: Englisch, Rubrik: Medizin // Andere Fachgebiete, Seiten: 308, Informationen: HC gerader Rücken kaschiert, Gewicht: 875 gr, Verkäufer: averdo

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Tumor Angiogenesis
155,00 € *
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Erscheinungsdatum: 17.02.2012, Medium: Buch, Einband: Gebunden, Titel: Tumor Angiogenesis, Redaktion: Ran, Sophia, Verlag: IntechOpen, Sprache: Englisch, Rubrik: Medizin // Andere Fachgebiete, Seiten: 308, Informationen: HC gerader Rücken kaschiert, Gewicht: 875 gr, Verkäufer: averdo

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Fractal Physiology of Tumor Angiogenesis
59,99 € *
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Angiogenesis is one fundamental element of tumor progression, since it is the process through which tumor develops its own vessel network and uses it to recruit nutrients from the host tissue. It is composed of several sub-processes that happen at different scales. Different mechanisms work first at a molecular and cellular level to promote the formation of the smaller capillaries, then others enables the maturation of the vessels and the organizations in a network structure. The link with the vascular network of the host tissue and the delivery of blood and nutrients complete the process. But, because the physiological effects acts as feedback, usually positive, at a molecular level, angiogenesis can be consider as a never-ending process, which shows several fractal properties. The aim of this work was to apply the concept of fractal physiology together with a multi-modality image approach to study the tumor angiogenesis in mouse model.

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History of Research on Tumor Angiogenesis
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In 1971, J. Folkman published in the “New England Journal of Medicine” a hypothesis that tumor growth is angiogenesis-dependent. Folkman introduced the concept that tumors probably secrete diffusible molecules that could stimulate the growth of new blood vessels toward the tumor and that the resulting tumor neovascularization could conceivably be prevented or interrupted by angiogenesis inhibitors. Solid and haematological tumors consist of an avascular and a subsequent vascular phase. Assuming that this depends on the release of angiogenic factors, acquisition of angiogenic capability can be seen as an expression of progression from neoplastic transformation to tumor growth and metastasis. Beginning in the 1980’s, the biopharmaceutical industry began exploiting the field of antiangiogenesis for creating new therapeutic compounds for modulating new blood vessels in tumor growth. In 2004, Avastin (Bevacizumab), a humanized anti-VEGF monoclonal antibody, was the first angiogenesis inhibitor approved by the Food and Drug Administration for the treatment of colorectal cancer. At present, it has been estimated that over 20,000 cancer patients worldwide have received experimental form of antiangiogenic therapy. This book offers a historical account of the relevant literature. It also emphasizes the crucial and paradigmatic role of angiogenesis as a biological process and the significance of antiangiogenic approach for the treatment of tumors.

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Research Directions in Tumor Angiogenesis
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Erscheinungsdatum: 06.02.2013, Medium: Buch, Einband: Gebunden, Titel: Research Directions in Tumor Angiogenesis, Redaktion: Chai, Jianyuan, Verlag: IntechOpen, Sprache: Englisch, Rubrik: Medizin // Andere Fachgebiete, Seiten: 302, Informationen: HC gerader Rücken kaschiert, Gewicht: 867 gr, Verkäufer: averdo

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Research Directions in Tumor Angiogenesis
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Erscheinungsdatum: 06.02.2013, Medium: Buch, Einband: Gebunden, Titel: Research Directions in Tumor Angiogenesis, Redaktion: Chai, Jianyuan, Verlag: IntechOpen, Sprache: Englisch, Rubrik: Medizin // Andere Fachgebiete, Seiten: 302, Informationen: HC gerader Rücken kaschiert, Gewicht: 867 gr, Verkäufer: averdo

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Tumor Angiogenesis
283,49 € *
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Erscheinungsdatum: 15.10.2007, Medium: Buch, Einband: Gebunden, Titel: Tumor Angiogenesis, Titelzusatz: Basic Mechanisms and Cancer Therapy, Redaktion: Marmé, Dieter // Fusenig, Norbert, Verlag: Springer-Verlag GmbH // Springer Berlin, Sprache: Englisch, Schlagworte: Krebs // Krankheit // Therapie // diverse // Onkologie // Radioonkologie // Forschung // medizinisch // psychologisch // Heilkunde // Humanmedizin // Medizin // Arznei // Arzneimittellehre // Pharmakologie // Chirurgie // Biologie // Molekularbiologie // Biochemie // Chemie // MEDICAL // Biochemistry // Oncology // Pharmacology, Rubrik: Innere Medizin // Chirurgie, Seiten: 845, Abbildungen: 82 schw.-w. und 288 farb. Abb., 29 schw.-w. Tabellen, Informationen: Gb, Gewicht: 2195 gr, Verkäufer: averdo

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Dominietto, Marco: Fractal Physiology of Tumor ...
68,00 € *
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Erscheinungsdatum: 06/2012, Medium: Taschenbuch, Einband: Kartoniert / Broschiert, Titel: Fractal Physiology of Tumor Angiogenesis, Titelzusatz: Theory, experiments and results, Autor: Dominietto, Marco, Verlag: LAP Lambert Academic Publishing, Sprache: Englisch, Rubrik: Medizin // Allgemeines, Lexika, Seiten: 196, Informationen: Paperback, Gewicht: 308 gr, Verkäufer: averdo

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