This is a comprehensive textbook that provides a detailed description of the imaging techniques and findings in patients with benign and malignant bone tumors. In the first part of the book, the various techniques and procedures employed for imaging bone tumors are discussed in detail. The second part of the book gives an authoritative review of the role of these imaging techniques in diagnosis, surgical staging, biopsy, and assessment of response to therapy. The third part of the book covers the imaging features of each major tumor subtype, with separate chapters on osteogenic tumors, cartilaginous tumors, etc. The final part of the book reviews the imaging features of bone tumors at particular anatomical sites such as the spine, ribs, pelvis, and scapula. Each chapter is written by an acknowledged expert in the field, and a wealth of illustrative material is included. This book will be of great value to musculoskeletal and general radiologists, orthopedic surgeons, and oncologists.
Detection and characterization of bone tumors with imaging remains a big challenge for every radiologist notwithstanding the impressive progress achieved by the introduction of several new imaging modalities. Moreover, new concepts in surgical and oncological treatment of these lesions require from the radiologist appropriate and focused answers to the specifc questions asked by the referring physicians in order to choose the best therapeutic approach for the in- vidual patient. Tis comprehensive textbook describes in detail the possibilities and limits of all moda- ties, including MRI, CT, nuclear medicine and interventional radiological procedures, employed for the modern imaging of tumoral and tumor-like lesions of bone. Teir role in the diagnosis, surgical staging, biopsy and assessment of response to therapy is discussed in detail, covering all tumor subtypes as well as their specifc anatomical location.Well selected and technically imp- cable illustrations strongly enhance the didactic value of this work. I am very much indebted and grateful to the three editors: A. Mark Davies, Murali Sundaram and Steven L. J. James, world authorities in musculoskeletal radiology, for their superb scientifc achievement in preparing and editing this wonderful volume as well as for their individual ch- ters. I would also like to thank the large international group of collaborating authors, who are also widely acknowledged for their specifc expertise in the area of bone tumors, for their outstanding contributions.
This book provides essential, internationally applicable information in the area of orthopedic pathology with emphasis on practical diagnostic aspects, including many illustrations: roentgenograms, CT-scans, MRI, scintigraphies, as well as pictures of gross surgical specimens and microphotographs, immunohistochemical reactions and genomics. Information on histopathological and molecular diagnosis, and basic therapeutic guidelines are provided. This book offers generous coverage of epidemiology, clinical features, radiology, pathology, differential diagnosis and treatment, not only for common lesions, but also those less frequently encountered. Clues in the images and histopathology needed to arrive at a sharp differential diagnosis are discussed. The content is arranged based on the World Health Organization's Consensus Classification, with the addition of other lesions not included therein. Tumors and Tumor-Like Lesions of Bone is aimed at general and specialised surgical pathologists, radiologists, orthopedic surgeons, and oncologists, in practice and in training.
Erscheinungsdatum: 17.09.2009, Medium: Buch, Einband: Gebunden, Titel: Imaging of Bone Tumors and Tumor-Like Lesions, Titelzusatz: Techniques and Applications, Auflage: 2009, Redaktion: Davies, A. Mark // James, Steven J. // Sundaram, Murali, Verlag: Springer Berlin Heidelberg // Springer-Verlag GmbH, Sprache: Englisch, Schlagworte: Chirurgie // Krebs // Krankheit // Onkologie // Radioonkologie // Orthopädie // Radiologie // Strahlen // Bildgebende Verfahren // Medizinische Bildverarbeitung: Radiologie // Orthopädie und Brüche, Rubrik: Medizin // Andere Fachgebiete, Seiten: 716, Informationen: HC runder Rücken kaschiert, Gewicht: 2101 gr, Verkäufer: averdo
Bone is a living tissue prone to develop a diverse array of inflammatory, metabolic, genetic, reactive, circulatory and neoplastic abnormalities. The Atlas of Bone Pathology describes and selectively illustrates the normal and pathologic conditions that afflict human bone, focusing heavily on tumor and tumor-like conditions of bone and their non-neoplastic mimics. Supplemented with radiographic and special study images, this extraordinary collection of high quality digital images aid continuing efforts to recognize, understand, and accurately interpret the light microscopic findings in bone specimens. Authored by nationally and internationally recognized pathologists, The Atlas of Bone Pathology is a concise and useful resource for both novice and seasoned pathologists alike.
In the age of the World Wide Web, informed patients continue to surprise oncologists with detailed questions about popular tumor therapies. Although minimally invasive tumor therapies (MITT) have become daily clinical practice for palliative treatment of liver tumors, the acceptance of these palliative modalities still varies enormously. In addition, promising results have been published for in situ ablation of lung metastases, bone tumors, and renal cell carcinoma. This book gives an up-to-date overview of the popular techniques and clinical results of MITT, with a clarification of the actual indications including the size, tumor entities, and clinical benefits. Moreover, the book focuses on the prospectives and limitations of imaging methods - ultrasound, computed tomography, and magnetic resonance imaging - used for MITT. TOC:Image guidance of minimal invasive tumor therapies: Use of imaging modalities for the guidance of minimal invasive tumor therapies. Development of navigation systems for image-guided laparoscopic tumor resections in liver surgery.- Methods: Radiofrequency ablation: the percutaneous approach. Radiofrequency ablation: the surgical approach. Laser-induced thermotherapy (LITT).- Clinical results: Liver metastases. Percutaneous ablation of hepatocellular carcinoma. Lung tumors. Renal tumors. Thermal ablation in bone tumors.
To date, there are many reports about the tumor progression and local invasion of ameloblastoma as well as bone resorption induced by the tumor cells. However, those studies have not described in detailed the histological features of ameloblastoma in terms of stroma and bone invasion. In this book therefore, discuss the stromal type with their sub types. In ameloblastoma, stroma acts not only in bone resorption but also causes suppression of new bone formation. sFRP-2, a Wnt antagonist is the main factor for the impaired bone formation. And activating RANKL with the help of TGF-¿1 induced osteoclastogenesis. It causes bone destruction without a proportional osteoblastic reaction, resulting in an uncoupling of the normal bone remodeling sequence. So, the final volume of the bone destruction was less with a large number of osteoblast. Therapies targeting the inhibition of sFRP-2 and RANKL may potentials be used in inhibiting ameloblastoma's growth as well as other osteolytic disease.
This book addresses the interactions and interrelationships between tumor and host that modulate progression and metastasis. A unique aspect of the book is that it highlights the tumor/host interactions as new targets for therapeutic intervention to control cancer. One promising approach is to target the host rather than the tumor itself, and several authors examine the potential for this novel tactic to oppress the manipulative cancer cell. The book examines the tumor and host relationship from multiple viewpoints: cellular and molecular events that occur during tumor-host cell interactions that control differentiation, cell proliferation, angiogenesis and vasculogenic mimicry, migration, apoptosis, invasion, metastasis. Other topics include the role of the immune response and chemokines/chemokine receptors, and the role of the brain and nutrients in tumor and host survival. Drug resistance limits cancer therapy, and the book emphasizes numerous novel and future therapeutic directions to sensitize drug resistant cells and other approaches that target the tumor and host microenvironment. This book will be of interest to cancer researchers who are interested in understanding metastasis, tumor and host interaction and interrelationships, and who have an interest in cancer control through development of novel targeting agents that impact these processes. TOC:Microenvironmental Effects on Tumour Progression and Metastasis.- Role of Microenvironment on Gene Expression, Angiogenesis and Microvascular Function in Tumors.- Imaging of Angiogenesis In Vivo with Fluorescent Proteins: Fluorescence Imaging of Angiogenesis.- The Epigenetic Influence of the Tumor Microenvironment on Melanoma Plasticity.- Dynamics of Cell Adhesion Interactions during Melanoma Development.- Matrix Metalloproteinases: Mediators of Tumour-Host Cell Interactions.- Role of Brain Microenvironment in Brain Metastases.- Influence of the Bone Microenvironment on Breast Cancer Metastasis to Bone.- Interaction of Tumour with Host Stroma in Hepatocellular Carcinoma.- Dynamic Nature of Tumour-Host Interactions Within the Tumor Microenvironment.- Breast Cancer Progression: A 'Vicious Cycle' of Pro-Malignancy Activities is Mediated by Inflammatory Cells, Chemokines and Cytokines.- 14 additional articles.
Tumors and Cancers: Skin - Soft Tissue - Bone - Urogenitals provides succinct reviews of neoplastic growths disrupting normal functions of affected structures. Each chapter presents a state of the art summary of tumor/cancer of a particular type in relation to its biology, epidemiology, disease mechanisms, clinical signs, diagnosis, treatment and prognosis.