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Future Aspects of Tumor Suppressor Gene
155,00 € *
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Erscheinungsdatum: 10.04.2013, Medium: Buch, Einband: Gebunden, Titel: Future Aspects of Tumor Suppressor Gene, Redaktion: Cheng, Yue, Verlag: IntechOpen, Sprache: Englisch, Rubrik: Biologie // Sonstiges, Seiten: 232, Informationen: HC gerader Rücken kaschiert, Gewicht: 719 gr, Verkäufer: averdo

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Stand: 07.12.2019
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Future Aspects of Tumor Suppressor Gene
155,00 € *
ggf. zzgl. Versand

Erscheinungsdatum: 10.04.2013, Medium: Buch, Einband: Gebunden, Titel: Future Aspects of Tumor Suppressor Gene, Redaktion: Cheng, Yue, Verlag: IntechOpen, Sprache: Englisch, Rubrik: Biologie // Sonstiges, Seiten: 232, Informationen: HC gerader Rücken kaschiert, Gewicht: 719 gr, Verkäufer: averdo

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Wilms' tumor gene 1 as an  immunotherapeutic ta...
39,99 € *
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Uterine high grade sarcoma and recurrent endometrial carcinoma are aggressive cancers with limited classical treatment options, resulting in a poor prognosis. The search for targeted treatments is urgently needed. In this research we focused in the first place on the detection of the highly immunogenic tumor-associated antigen Wilms' tumor gene 1 (WT1) in uterine tumors. The next step was to develop a targeted treatment against WT1, based on dendritic cell immunotherapy.

Anbieter: Thalia AT
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Coosemans, A: Wilms' tumor gene 1 as an immunot...
44,90 € *
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Erscheinungsdatum: 14.02.2014, Medium: Taschenbuch, Einband: Kartoniert / Broschiert, Titel: Wilms' tumor gene 1 as an immunotherapeutic target in uterine cancer, Autor: Coosemans, An // Van Gool, Stefaan, Verlag: LAP Lambert Academic Publishing, Sprache: Englisch, Rubrik: Medizin // Allgemeines, Lexika, Seiten: 144, Informationen: Paperback, Gewicht: 231 gr, Verkäufer: averdo

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Alam, M Shabbir: Cancer of Uterine Cervix and P...
59,00 € *
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Erscheinungsdatum: 02/2011, Medium: Taschenbuch, Einband: Kartoniert / Broschiert, Titel: Cancer of Uterine Cervix and PTEN tumor suppressor gene, Titelzusatz: Genetic and Epigenetic alterations in PTEN gene among Cervical Cancer patients, Autor: Alam, M Shabbir // Moshahid A Rizvi, M, Verlag: LAP Lambert Acad. Publ., Sprache: Englisch, Rubrik: Medizin // Andere Fachgebiete, Seiten: 132, Informationen: Paperback, Gewicht: 213 gr, Verkäufer: averdo

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Regulation of Gene Expression in the Tumor Envi...
193,19 € *
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Erscheinungsdatum: 30.11.2010, Medium: Taschenbuch, Einband: Kartoniert / Broschiert, Titel: Regulation of Gene Expression in the Tumor Environment, Titelzusatz: Regulation of melanoma progression by the microenvironment: the roles of PAR-1 and PAFR, Auflage: Softcover reprint of hardcover 1st ed. 2008, Redaktion: Bar-Eli, Menashe, Verlag: Springer Netherlands // Springer Netherland, Sprache: Englisch, Schlagworte: Zellbiologie // Zytologie, Rubrik: Allgemeinmedizin // Diagnostik, Therapie, Seiten: 160, Informationen: Paperback, Gewicht: 254 gr, Verkäufer: averdo

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ESPLIN, E: Tumor suppressor gene activity in lu...
49,00 € *
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Erscheinungsdatum: 12/2009, Medium: Taschenbuch, Einband: Kartoniert / Broschiert, Titel: Tumor suppressor gene activity in lung, colon and breast carcinomas, Titelzusatz: PPP2R1B mechanisms of tumorigenesis and heritable cancer susceptibility, Autor: ESPLIN, EDWARD, Verlag: LAP Lambert Acad. Publ., Sprache: Englisch, Rubrik: Genetik // Gentechnologie, Seiten: 80, Informationen: Paperback, Gewicht: 136 gr, Verkäufer: averdo

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Microarray Technology and Cancer Gene Profiling
178,49 € *
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Cancer is a heterogeneous disease in most respects, including its cellularity, different genetic alterations and diverse clinical behaviors. Traditional molecular analyses are reductionist, assessing only one or a few genes at a time, thus working with a biologic model too specific and limited to confront a process whose clinical outcome is likely to be governed by the combined influence of many genes. The potential of functional genomics is enormous, because for each experiment, thousands of relevant observations can be made simultaneously. Accordingly, DNA array, as other high throughput technologies, might catalyze and ultimately accelerate the development of knowledge in tumor cell biology. Although in its infancy, the implementation of DNA array technology in cancer research has already provided investigators with novel data and intriguing new hypotheses on the molecular cascade leading to cancerogenesis, tumor aggressiveness and sensitivity to antineoplastic agents. Given the revolutionary implications that the use of this technology might have in the clinical management of cancer patients, principles of DNA array-based tumor gene profiling need to be clearly understood for the data to be correctly interpreted and appreciated. In the present book, written by leading experts in each field, the technical features characterizing this powerful laboratory tool are discussed, and the applications so far described in the field of oncology are reviewed. TOC:Manufacturing of Microarrays.- Technological Platforms for Microarray Gene Expression Profiling.- Principles of Gene Microarray Data Analysis.- Gaining Weights and Feeling Good About It!- Complementary Techniques: RNA Amplification for Gene Profiling Analysis.- Complementary Techniques: Laser Capture Microdissection - Increasing Specificity of Gene Expression Profiling of Cancer Specimens.- Complementary Techniques: Validation of Gene Expression Data by Quantitative Real Time PCR.- Microarrays for Cancer Diagnosis and Classification.- Gene Profiling for the Prediction of Tumor Response to Treatment: the Case of Immunotherapy.- Identification of Molecular Determinants of Tumor Sensitivity and Resistance to Anticancer Drugs.- SNP and Mutation Analysis.- Cancer Development and Progression.- Gene Expression Profiling in Malignant Lymphomas.- Tumor Immunology.- Index.

Anbieter: Thalia AT
Stand: 07.12.2019
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Gene Therapy for Cancer
226,09 € *
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The possibility of treating cancer, a disease frequently defined by genetic defects, by introducing genes that target these very alterations has generated tremendous enthusiasm. This enthusiasm, however, has been tempered by an increasing number of obstacles to successful therapy, including vector systems that do not reach systemic metastases, therapeutic genes with redundant mechanisms allowing for cellular resistance, and toxicities in clinical trials that result in premature closure. The three comprehensive sections of this volume present currently available cancer gene therapy techniques, with specific attention to these trouble spots. Part I describes the various aspects of gene delivery including vehicles, or vectors, and their respective characteristics and production methods. In Part II, the contributors discuss strategies and targets for the treatment of cancer, including methods for cell-death therapies, correction of underlying genetic defects at the molecular level, and activation of the immune system or tumor microenvironment. The contributors provide a succinct framework for understanding the basic underlying oncogenic changes, which encourages the development of vectors engineered to exploit these gene mutations through selective spread of the vector in tumor cells with the specific changes. Finally, in Part III, experts in clinical gene therapy trials discuss the difficulties inherent in bringing gene therapy treatment for cancer to the clinic, and principal investigators present gene therapy approaches in the clinical testing stage and the results that have reached the stage of clinical testing. of these trials. TOC:Adenovector-mediated Cancer Gene Therapy.- Efficacy, Toxicity and Immunogenicity of Adenoviral vectors.- Lentiviral and Retroviral Vector Systems.- Vaccinia and Pox-Virus.- Spinning Straw into Gold: The Potential of Replicating Herpes Simplex Virus as a Therapy for Cancer revealed by Genetic Alchemy.- Alphavirus Vectors for Gene Therapy Applications.- Vesicular Stomatitis Virus and RNA Viruses as Gene Therapy Vectors.- Parvovirus Vectors.- Non-Viral Vector Systems.- Oncogenes, Tumor Suppressor Genes, and Apoptosis-Inducing Genes Utilized in Cancer Gene Therapy.- Gene Silencing Therapy against Cancer.- Tumor Targeting-Retargeted Adenovirus.- Herpes Simplex Mediated Gene Therapy: Preclinical and and Clinical Approaches.- Cytokine Gene Therapy for Genitourinary Cancer.- Combination of Gene Therapy with Radiation.- Gene Transfer into Hematopoietic Stem Cells for Chemoprotection andin vivo Selection.- Non-Viral Genetic Vaccines for Cancer.- Gene Therapy Targeted at Angiogenesis and Lymphangiogenesis for Cancer Treatment.- Tumor-Specific Replicating Adenoviruses: Delta 24 for Human Gliomas.- Problems, Side Effects and Disappointments in Clinical Cancer Gene Therapy.- Trials and Tribulations in Developing Clinical Trials of Gene Therapy: E1A for Breast or Ovarian Cancer.- Phase I Clinical Experience with Intravenous Administration of PV701, an Oncolytic Virus.- MDA-7/IL-24 as a Multi-Modality Therapy for Cancer.- Development of Therapeutic Genes for Breast Cancer Treatment.- Steps in a Translational Cancer Gene Therapy Trial.

Anbieter: Thalia AT
Stand: 07.12.2019
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