After 68 -year-old David Granger crashes his BMW, medical tests reveal a brain tumor that he readily attributes to his wartime Agent Orange exposure. He wakes up from surgery repeating a name no one in his civilian life has ever heard - that of a Native American soldier whom he was once ordered to discipline. David decides to return something precious he long ago stole from the man he now calls Clayton Fire Bear. It might be the only way to find closure in a world increasingly at odds with the one he served to protect. It might also help him finally recover from his wife's untimely demise. As David confronts his past to salvage his present, a poignant portrait emerges: that of an opinionated and goodhearted American patriot fighting like hell to stay true to his red, white, and blue heart, even as the country he loves rapidly changes in ways he doesn't always like or understand. Hanging in the balance are Granger's distant art-dealing son, Hank; his adoring seven-year-old granddaughter, Ella; and his best friend, Sue, a Vietnamese-American who respects David's fearless sincerity. Through the controversial, wrenching, and wildly honest David Granger, Matthew Quick offers a no-nonsense but ultimately hopeful view of America's polarized psyche. By turns irascible and hilarious, insightful and inconvenient, David is a complex, wounded, honorable, and ultimately loving man. The Reason You're Alive examines how the secrets and debts we carry from our past define us; it also challenges us to look beyond our own prejudices and search for the good in our supposed enemies. 1. Language: English. Narrator: R.C. Bray. Audio sample: http://samples.audible.de/bk/macm/001237/bk_macm_001237_sample.mp3. Digital audiobook in aax.
The New York Times best-selling author of The Silver Linings Playbook offers a timely novel featuring his most fascinating character yet, a Vietnam vet embarking on a quixotic crusade to track down his nemesis from the war. After 68-year-old David Granger crashes his BMW, medical tests reveal a brain tumor that he readily attributes to his wartime Agent Orange exposure. He wakes up from surgery repeating a name no one in his civilian life has ever heard - that of a Native American soldier whom he was once ordered to discipline. David decides to return something precious he long ago stole from the man he now calls Clayton Fire Bear. It may be the only way to find closure in a world increasingly at odds with the one he served to protect. It may also help him to finally recover from his wife's untimely demise. As David confronts his past to salvage his present, a poignant portrait emerges: that of an opinionated and good-hearted American patriot fighting like hell to stay true to his red, white, and blue heart, even as the country he loves rapidly changes in ways he doesn't always like or understand. Hanging in the balance are Granger's distant art-dealing son, Hank; his adoring seven-year-old granddaughter, Ella; and his best friend, Sue, a Vietnamese American who respects David's fearless sincerity. Through the controversial, wrenching, and wildly honest David Granger, Matthew Quick offers a no-nonsense but ultimately hopeful view of America's polarized psyche. By turns irascible and hilarious, insightful and inconvenient, David is a complex, wounded, honorable, and loving man. The Reason You're Alive examines how the secrets and debts we carry from our pasts define us; it also challenges us to look beyond our own prejudices and search for the good in us all. 1. Language: English. Narrator: R.C. Bray. Audio sample: http://samples.audible.de/bk/harp/006144/bk_harp_006144_sample.mp3. Digital audiobook in aax.
If you want to fight cancer, what should you eat? Do you believe that prevention is better than cure? Also, do you fear that your lifestyle isn’t healthy and may lead to serious illness? Or do you want to understand the diet’s relationship with cancer?The alkaline diet is the ultimate cancer-fighting diet due to its ability to provide all necessary nutrients that the body lacks to kick in its natural defenses. You see, a healthy body already has an internal mechanism that fights diseases and infections, including cancer. However, with our diet, we have weakened our system so that when some cancer cells come to be, for one reason or the other, our bodies are not well equipped to handle the challenge.It is also true that with the current diet, we have created quite a toxic environment so that our cells are surrounded by a toxic acidic environment that incites mutation. When a normal cells begins to go through the mutation process, it begins to subdivide and multiply at an incredibly rapid speed, so that tumors begin to develop. With time, a benign tumor can turn malignant, and the individual receives the earth-shattering diagnosis.With the alkaline diet, a positive cancer diagnosis should not scare you because with the diet, you will pack your body with the proper cancer-fighting nutrients and antioxidants, so that you remain healthy, and strong throughout your fight. You will be happy to know that there are some target foods you can take to intensify the fight for whichever cancer type you are battling.To that end, this audiobook brings together the most accurate information in regards to cancer, the alkaline diet, the interaction between the two, information about diet pH, and other critical details you ought to know as you dive into this pool of health. You will have a guide on the foods you can eat so that you do not keep guessing what you can and cannot eat. You will also be happy to know that this diet is not as restrictive 1. Language: English. Narrator: Lizzie Richards. Audio sample: http://samples.audible.de/bk/acx0/163302/bk_acx0_163302_sample.mp3. Digital audiobook in aax.
Interferon Regulatory Factor-2 is a vertebrate transcription factor having oncogenic nature, it antagonises Interferon Regulatory Factor-1, a tumor suppressor gene, functions. Knockout mice for IRF-2 gene showed defect in B-cell lymphopoeisis, they died following LCMV (Lymphocytic Choriomeningitis Virus) infections. IRF-2 is functionally just opposite of IRF-1. Interestingly, one would have thought that as IRF-1-/- (knock-out) mice showed lack of CD8+T cells and low cytotoxicity of NK cells, the over production of IRF-2 in mice may restore it. But it does not happen so, the reason being unknown. However, IRF-2 binds at Interferon Stimulated Response Element sequence in viral infected cell. This book is about mouse IRF-2 gene cDNA cloning and expression of chimeric protein in E.coli. This study will serve as a platform for further functional analysis of chimeric IRF-2, which is potent oncogene in aberrant conditions.
Chemokines play an important role in the onset and development of inflammatory diseases. In addition, due to the systemic inflammatory response syndrome which develops after onset of the diseases, complications of other organs results in the development of multiple organ dysfunction. Being a significant activator for neutrophils, the chemokine IL-8 plays an important role in the cascade of inflammation. Like many other inflammatory diseases (psoriasis, rheumatoid arthritis, lung disease), that the levels of serum IL-8 serum are overexpressed in Acute pancreatitis. At the same time, the extensive effects of increased IL-8 activity on tumor pathogenesis make it a unique therapeutic target in cancer therapy. For example, IL-8 promotes tumor growth, angiogenesis, and metastasis in murine models of several cancers. Moreover, blocking IL-8 activity with a monoclonal antibody has been shown to decrease tumor growth in two murine cancer models. Blockade of IL-8 expression in some human melanoma cell lines by antisense RNA has shown that IL-8 functions as an autocrine growth modulator for these cells. So, IL-8 may be important for inflammation and cancer as a reason.
Despite the advances that lived science and medicine in recent decades, the prevalence and above all, the survival of patients with oral and, head and neck cancer, has not improved. Patients are diagnosed in advanced stages, where radiotherapy / surgery / chemotherapy are the only alternatives and do not provide acceptable results in most cases. For this reason, we believe that research at the basic level is the key to know more deeply the pathogenesis of these tumors. The cell cycle regulation is the basic mechanism of self-monitoring of healthy cells, which is fully deregulated in cancer, which causes an excessive and uncontrolled growth of tumor cells. In this special issue, we will try to elucidate the role of p16 and p21 in cell cycle control in oral squamous cell carcinoma, with the aim of translationally, apply the results to clinical practice.
The area of cancer research has become a very actively researched field. The different transitions from cell division to apoptosis are recently under extensive investigations. Apoptosis is a generally controlled mechanism of cell death that is essential for the elimination of cells that can no longer replicate or that have potentially mutagenic damage during normal development and for the maintenance of tissue homeostasis. Research in and around apoptosis has increased substantially since the early 1990s. In addition to its importance as a biological phenomenon, defective apoptotic processes have been implicated in an extensive variety of diseases. Development of drug resistance in tumor cells is common occurrence, and is the primary reason for failure of chemotherapy. A number of biochemical changes could contribute to the development of cellular resistance to chemotherapy. The book is the outgrowth of Ph.D. dissertation that shed the light on new mechanisms that might contribute to cancer development and/or progression and elucidate molecular based-variation that is important from both basic and clinical perspectives.
High Quality Content by WIKIPEDIA articles! The odontoma is a hamartoma of odontogenic origin. The average age of people found with an odontoma is 14, and the condition is frequently associated with an unerupted tooth. 22% of odontogenic tumors are odontomas. A hamartoma is a benign,focal malformation that resembles a neoplasm in the tissue of its origin. This is not a malignant tumor, and it grows at the same rate as the surrounding tissues. It is composed of tissue elements normally found at that site, but which are growing in a disorganized mass. They occur in many different parts of the body and are most often asymptomatic and undetected unless seen on an image taken for another reason.
Certain specific antigens, which behave as oncoproteins, are present in normal fetal/neonatal developing brain. It was demonstrated that a convergence exists between ontogenesis and onco-genesis. The most malignant example of central nervous system neoplasia is glioblastoma multiforme. The biomarker - oncoprotein - characteristic of glial fetal and tumoral cells, but not neuronal cells, is IGF-I. For this reason, for therapy purpose, the arrest of IGF-I synthesis in cancer glial cells of glioblastoma was performed using in vitro anti - gene anti IGF-I strategy (IGF-I antisense /triple helix, AS/TH). The created AS/TH cells, became immunogenic and expressed MHC-I, B71 antigens. The AS/TH cells while injected in glioblastoma patients, induced the antitumor immune response and stopped the progression of tumor development. The survival of treated glioblastoma patients reached 2 years, and in some cases, up to 3-4 years. The established Anti - Gene IGF-I cancer immunotherapy was introduced in USA, Europe, China and Latin America.