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Biopsy Interpretation of the Kidney & Adrenal G...
117,99 € *
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Biopsy Interpretation of the Kidney and Adrenal GlandThis practical volume in the Biopsy Interpretation Series is your guide to effective diagnostic biopsy of the kidney and adrenal glands. Presented in a reader-friendly format, the text includes abundant photomicrographs of actual biopsy samples as well as correlative photos of surgical specimens and ancillary immunohistochemical studies. Each organ is addressed in a separate section that includes an introduction to biopsy techniques and an overview of normal histology. Positive diagnoses for renal lesions are described by tumor type. Adrenal lesions are grouped by primary and metastatic tumors, reflecting the main diagnostic considerations at the adrenal site. Uniquely detailed focus addresses the specific techniques and interpretive features of renal and adrenal biopsy. Timely content addresses the use of renal biopsy in minimally invasive therapeutic techniques as well as its role in active surveillance of renal masses. The latest ISUP classifications reflect newly described renal tumors discussed at the March 2012 USCAP annual meeting. Clinical implications of each diagnosis are highlighted throughout the text to guide therapeutic decision-making.

Anbieter: buecher
Stand: 06.12.2020
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Biopsy Interpretation of the Kidney & Adrenal G...
117,99 € *
ggf. zzgl. Versand

Biopsy Interpretation of the Kidney and Adrenal GlandThis practical volume in the Biopsy Interpretation Series is your guide to effective diagnostic biopsy of the kidney and adrenal glands. Presented in a reader-friendly format, the text includes abundant photomicrographs of actual biopsy samples as well as correlative photos of surgical specimens and ancillary immunohistochemical studies. Each organ is addressed in a separate section that includes an introduction to biopsy techniques and an overview of normal histology. Positive diagnoses for renal lesions are described by tumor type. Adrenal lesions are grouped by primary and metastatic tumors, reflecting the main diagnostic considerations at the adrenal site. Uniquely detailed focus addresses the specific techniques and interpretive features of renal and adrenal biopsy. Timely content addresses the use of renal biopsy in minimally invasive therapeutic techniques as well as its role in active surveillance of renal masses. The latest ISUP classifications reflect newly described renal tumors discussed at the March 2012 USCAP annual meeting. Clinical implications of each diagnosis are highlighted throughout the text to guide therapeutic decision-making.

Anbieter: buecher
Stand: 06.12.2020
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Renal Tumor
133,99 € *
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Renal Tumor ab 133.99 EURO A Cell Carcinoma

Anbieter: ebook.de
Stand: 06.12.2020
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Renal Tumor
128,99 € *
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Renal Tumor ab 128.99 EURO

Anbieter: ebook.de
Stand: 06.12.2020
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Cancer chemotherapy and nephrotoxicity
54,90 € *
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Doxorubicin (Dox) is an anthracycline glycoside antibiotic that possesses a potent and broad spectrum anti-tumor activity against variety of human solid tumors and hematological malignancies. However its use in chemotherapy has been limited largely due to its diverse toxicities, including cardiovascular, renal, hepatic, hematological and testicular toxicity.Doxorubicin induces changes in the renal tissue of rats which includes increased glomerular capillary permeability and tubular atrophy. Although the exact mechanism of Dox-induced nephrotoxicity remains unknown, it is believed to be mediated through multifactorial mechanisms including free radical formation, iron dependent oxidative damage of biological macromolecules and membrane lipid peroxidation.

Anbieter: Dodax
Stand: 06.12.2020
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Brain Tumors. Pt.1
280,84 € *
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The classification of brain tumors is up-dated using magnetic resonance spectroscopy technology. The role of cellular immortality in brain tumors is reviewed. Tumor to tumor metastases are a common occurrence, for example, , brain metastasis from breast cancer, lung cancer, and renal cancer is discussed. Genetic profiling and treatment (including neurosurgery) of such brain cancers are explained. Breast cancer patients treated with certain drugs (e.g., capecitabine and lapatinib can develop CNS tumors. Role of brain tumor suppressor genes (e.g., NRP/B gene) is pointed out. Biomarkers used to diagnose brain malignancies are explained in detail. A number of imaging modalities used for diagnosing and assessing the effectiveness of treatments of brain tumors are presented. The imaging methods discussed include MRI, PET, CT, MRSi, and SPECT. Also, is discussed the impact of PET using radiolabeled amino acids on brain tumors.

Anbieter: Dodax
Stand: 06.12.2020
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Brain Metastases
163,42 € *
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This book describes the role of advanced neuroimaging techniques in characterizing the changes in tissue structure in patients with brain metastases. On a large number of newly recognized CT, MRI, and PET characteristics of brain metastases from different primary tumors are highlighted, thereby elucidating the potential differential diagnostic role of CT perfusion imaging, MR spectroscopy, MR diffusion-weighted imaging, MR susceptibility-weighted imaging, and PET with different radiopharmaceuticals. For example, the different manifestations of metastases of melanoma, renal cell carcinoma, and ovarian cancer on MRI and CT perfusion imaging are described, and the role of MR susceptibility-weighted imaging in the differential diagnosis of glioblastoma multiforme and metastatic tumors is clarified. Metastases of colon cancer have shown a special manifestation on T2 weighted images. The book also presents novel findings regarding pathogenesis and tumor biology and describes qualitative and quantitative changes in tumor tissue and alterations in brain white matter due to surrounding tumor growth.Neuroradiologists and others, including neurosurgeons, neurologists, and nuclear medicine physicians, will find that this book offers a fascinating insight into the ways in which newly available data on structural, hemodynamic, and metabolic changes are enriching the neuroimaging of brain metastases.

Anbieter: Dodax
Stand: 06.12.2020
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Prognostic indicators in Wilms' tumor
54,90 € *
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a)Introduction of problem: The significant prognostic factors of Wilms' tumor are- stage, age, anaplasia, size, capsular invasion, etc. The role of DNA ploidy, proliferation markers is still not proven. b)Abstract: Aims: This study was done to analyze the histopathological spectrum of pediatric renal tumors and to study the expression of Ki67, p53 and p27 in WT and correlate their expression in epithelial and blastema components in different stages of WT. Results: It was observed that the PI of Ki67 of epithelial component was significantly higher than that of blastema component in all stages. Proliferation index in stage II was significantly higher than stage I. Statistical analysis could not be done in stage III and stage IV due to small number of cases. p53 and p27 expression did not show any significant difference in epithelial and blastema components and in between stages. Conclusion: We found the differences of PI in different tissue components of WT. The epithelial component having higher PI of Ki67, which correlated well with the stage of advancement of the disease. c) Target group: The book was written for the pathologists, pediatric surgeons and urologists.

Anbieter: Dodax
Stand: 06.12.2020
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Mitochondrial Alterations in Solid Carcinomas
49,00 € *
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Alterations of the respiratory chain and mutations of the mitochondrial DNA (mtDNA) have been extensively investigated in a wide variety of neoplasias. However, no obvious correlation of a certain type of tumor and mtDNA mutations has been reported so far. I compared both, enzymatic measurements of the respiratory chain and mtDNA mutations in renal carcinomas and renal oncocytomas. To enable a high throughput screen of mtDNA variations, I developed a DHPLC-based protocol for a rapid detection of unknown variations of the entire human mtDNA. The benign renal oncocytomas were in clear contrast to the malign renal carcinomas. The oncocytomas showed significantly increased Krebs cycle- and OXPHOS enzyme activities, except a total breakdown of the complex I enzyme activity. The mutation screening revealed frame shift mutations, encoding mitochondrial ND genes in 8 out of 12 oncocytomas. All these somatic frame shift mutations displayed a homoplasmy of 100%. This study shows for the first time a direct correlation of mtDNA mutations in a specific type of cancer, which leads to a total lack of complex I enzyme activity in the respiratory chain.

Anbieter: Dodax
Stand: 06.12.2020
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