Erscheinungsdatum: 05/2011, Medium: Buch, Einband: Gebunden, Titel: Tumor-Associated Fibroblasts and their Matrix, Auflage: Edition, Redaktion: Mueller, Margareta M. // Fusenig, Norbert, Verlag: Springer-Verlag GmbH // Springer Netherland, Sprache: Englisch, Schlagworte: Biomedizin // Medizin // Krebs // Krankheit // Tumor // Onkologie // Radioonkologie // Forschung // medizinisch // psychologisch // Heilkunde // Humanmedizin // Vorklinische Medizin // Grundlagenwissenschaften, Rubrik: Allgemeinmedizin // Diagnostik, Therapie, Seiten: 452, Herkunft: NIEDERLANDE (NL), Reihe: The Tumor Microenvironment (Nr. 4), Informationen: Book, Gewicht: 817 gr, Verkäufer: averdo
Erscheinungsdatum: 27.11.2013, Medium: Taschenbuch, Einband: Kartoniert / Broschiert, Titel: Tumor-Associated Fibroblasts and their Matrix, Auflage: 2011, Redaktion: Fusenig, Norbert E. // Mueller, Margareta M., Verlag: Springer Netherlands // Springer Netherland, Sprache: Englisch, Schlagworte: Onkologie, Rubrik: Allgemeinmedizin // Diagnostik, Therapie, Seiten: 472, Informationen: Paperback, Gewicht: 709 gr, Verkäufer: averdo
Erscheinungsdatum: 04/2013, Medium: Buch, Einband: Gebunden, Titel: Endocrine Tumor Syndromes and Their Genetics, Redaktion: Stratakis, C. A., Verlag: Karger Verlag // Karger, S, Sprache: Englisch, Schlagworte: Endokrinologie // Krebs // Krankheit // Onkologie // Radioonkologie // Genetik // Humangenetik // Pathologie // des Menschen // Neurologie // Neurophysiologie // Physiologie // Chirurgie // Gesundheitsmanagement // management // Gesundheit // Gesundheitswesen // MEDICAL // Endocrinology & Metabolism // Internal Medicine // Genetics // Medizin // Neurologie und klinische Neurophysiologie // Chirurgische Techniken // Medizinverwaltung und, Rubrik: Medizin // Andere Fachgebiete, Seiten: 188, Abbildungen: in Color: 8 Tables: 24, Reihe: Frontiers of Hormone Research (Nr. 41), Gewicht: 748 gr, Verkäufer: averdo
It is now becoming very clear that the development and progression of tumor towards the malignant (metastatic) phenotype depends tightly on the interaction between the tumor cells and the tumor microenvironment. Tumor cells respond to stimuli generated within the tumor microenvironment for their growth advantage while the tumor cell themselves reshape and remodel the architecture and function of their extracellular matrices. The term tumor microenvironment is a wide umbrella consisting of stromal cells such as fibroblasts and endothelial cells and infiltration immune cells including T and B cells, macrophages, and other inflammatory cells (PMNs). These different components of the tumor microenvironment could have stimulatory and inhibitory effects on tumor progression by regulating the gene expression repertoire within the tumor cells on one hand and the stroma cells on the other. In this volume we have seven contributors who will discuss several different aspects on the cross talk within the tumor microenvironment components leading to the acquisition of the metastatic phenotype. It is our hope that these state-of-the-art studies will shed further light on our understanding of these complicated processes. TOC:1, Regulation of Melanoma Progression by the Tumor Microenvironment: the Roles of PAR-1 and PAFR.- 2, Functions of Autocrine Motility Factor at the Tumor Microenvironment.- 3, Targeting Signaling Pathways - in the search of Melanoma's Achilles' heel.- 4, Regulation of Gene Expression in Tumor and Non-Tumor Cells in the Tumor Microenvironment. Impact of ErbB2 Over-Expression on Tumor and Tumor Microenvironment that facilitate tumor progression and metastasis.- 5, Intercellular and Cytoskeletal Signaling Converge at PAK's.- 6, Molecular Basis for Vascular Endothelial Growth Factor Expression Tumor.- 7, Incipent Event in Human carcinogenesis: A Concept of Forerunner Genes.
The growing knowledge on tumor-immune response interactions and on the tumor microenvironment did not translate so far into better control of cancer by anti-tumor vaccination. The percentage of patients who benefited from vaccination strategies is still too small to justify their general use. It is the aim of this book to present an alternative to the conventional approach of developing injected tumor vaccines to activate anti-tumor immunity, which will fight cancer. It is argued that in situ tumor ablation (destruction) that involves tumor antigen release; cross presentation and the release of danger associated molecular patterns (DAMPs) can make the tumor its own cellular vaccine. Tumor ablation methods using chemicals, radiation, photodynamic therapy, cryoablation, high-temperature, radiofrequency, high intensity focused ultrasound, and electric-based ablation have been developed for focal tumors. In this book experts will deal with two main topics: I. What are the principles of the various ablation modalities, and II. How each method affects the tumor cells and their microenvironment, and how these effects are responsible for the induction of specific anti-tumor immunity. The aims of this book are thus: 1. Familiarize the readers with various methods of in situ tumor ablation. 2. Review the literature and stimulate comparisons on the efficacy of different ablation methods for the treatment of tumors of different histotypes. 3. Review the literature on the effects of various ablation methods on systemic and local anti tumor immunity and on other manifestations of the interactions of tumors with their microenvironment. 4. Stimulate comparative studies on the immunostimulatory effects of different ablation modalities.
Cancer cells are continuously interacting with the immune system of the host. These interactions can be regarded as a double edged sword. On the one hand, innate and adaptive immune responses act to protect the host by attempting rejection of the tumor. On the other hand, inflammatory cells and proteins stimulate multiplication and dissemination of cancer cells, thereby accelerating the progression of the disease. Traditionally, the interplay between cancer cells and host immunity has been studied systemically, with no particular attention to the site at which a given tumor develops. Recent studies, however, indicate that the tumor microenvironment is unique in providing both supportive and inhibitory factors that determine the fate of the tumor and its host. Accordingly, microenvironmental immunity that operates inside and around a tumor plays a crucial role in cancer development and progression. The aim of the present volume is to compile reviews on innate and adaptive immune responses at the tumor microenvironment with emphasis on positive and negative outcomes that affect the progression of the disease. These reviews have been solicited from experts in the field who published original research studies focusing on these issues. TOC:Foreword - Tumor Microenvironment under the Magnifying Glass: A New Challenge to Cancer Immunologists. 1: Immune Effector Cells in the Tumor Microenvironment: Their Role in Regulation of Tumor Progression. 2: Histocompatibility Antigens, Tumor Microenvironment and Escape Mechanisms Utilized by Tumor Cells. 3: Local Tumor Growth and Spontaneous Systemic T cell Responses in Cancer Patients: a Parodox and Puzzle. 4: Insights into mechanisms of immune resistance in the tumor microenvironment through molecular profiling. 5: Tumor Antigens as Modulators of the Tumor Microenvironment. 6: Tumor Cell Resistance to Apoptosis by Infiltrating Cytotoxic Lymphocytes. 7: The Tumor Microenvironment as a Model for Tissue-Specific Rejection. 8: Functional Cytotoxicity of T Cells at the Tumor Environment. 9: Natural Killer Cells at the Tumors Microenvironment. 10: Contribution of the Microenvironment to the Pathogenesis of EBV-positive Hodgkin and NK/T-cell Lymphomas.
Tumor-Induced Immune Suppression - Prospects and Progress in Mechanisms and Therapeutic Reversal presents a comprehensive overview of large number of different mechanisms of immune dysfunction in cancer and therapeutic approaches to their correction. This includes the number of novel mechanisms that has never before been discussed in previous monographs. The last decades were characterized by substantial progress in the understanding of the role of the immune system in tumor progression. Researchers have learned how to manipulate the immune system to generate tumor specific immune response, which raises high expectations for immunotherapy to provide breakthroughs in cancer treatment. It is increasingly clear that tumor-induced abnormalities in the immune system not only hampers natural tumor immune surveillance, but also limits the effect of cancer immunotherapy. Therefore, it is critically important to understand the mechanisms of tumor-induced immune suppression to make any progress in the field and this monograph provides these important insights.
Detection and characterization of bone tumors with imaging remains a big challenge for every radiologist notwithstanding the impressive progress achieved by the introduction of several new imaging modalities. Moreover, new concepts in surgical and oncological treatment of these lesions require from the radiologist appropriate and focused answers to the specifc questions asked by the referring physicians in order to choose the best therapeutic approach for the in- vidual patient. Tis comprehensive textbook describes in detail the possibilities and limits of all moda- ties, including MRI, CT, nuclear medicine and interventional radiological procedures, employed for the modern imaging of tumoral and tumor-like lesions of bone. Teir role in the diagnosis, surgical staging, biopsy and assessment of response to therapy is discussed in detail, covering all tumor subtypes as well as their specifc anatomical location.Well selected and technically imp- cable illustrations strongly enhance the didactic value of this work. I am very much indebted and grateful to the three editors: A. Mark Davies, Murali Sundaram and Steven L. J. James, world authorities in musculoskeletal radiology, for their superb scientifc achievement in preparing and editing this wonderful volume as well as for their individual ch- ters. I would also like to thank the large international group of collaborating authors, who are also widely acknowledged for their specifc expertise in the area of bone tumors, for their outstanding contributions.
Tumor markers is a vast and rapidly changing field which if properly understood can help in unravelling the mystery that shrouds the treatment and prognosis of oral cancer. though a plethora of tumor markers are available for exploration but their sensitivity and specificity varies. very few tumor markers are specific for a particular cancer. we the authors have tried to present the various tumor markers in a lucid form for both clinicians and students alike...!!!